Chelban, 2017: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
No
|
Spasticity, lower limb
Cognitive impairment Mri brain other abnormalities |
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
No
|
Spasticity, lower limb
|
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
No
|
Central motor conduction time abnormality
Seizures Nerve conduction studies other abnormalities Spasticity, lower limb Peripheral neuropathy on nerve conduction studies Show more (+2) |
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
No
|
Spasticity, lower limb
|
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
No
|
Spasticity, lower limb
|
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
No
|
Cognitive impairment
Dysphagia Seizures Spasticity, lower limb Central motor conduction time abnormality Peripheral neuropathy on nerve conduction studies Nerve conduction studies other abnormalities Show more (+4) |
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
No
|
Ophthalmoplegia
Gait ataxia Spasticity, lower limb |
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
No
|
Nerve conduction studies other abnormalities
Central motor conduction time abnormality Spasticity, lower limb Peripheral neuropathy on nerve conduction studies Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
No
|
Spasticity, lower limb
|
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
No
|
Seizures
Spasticity, lower limb |
n.a.
|