Yes

♂

C

BRA

n.a.

46

Yes

Brain calcification
-Motor

n.a.

p.Leu119Pro: het

No

♂

C

FRA

63

63

Yes

Brain calcification
-Motor
Parkinsonism
Cognitive decline
Psychotic sign/sympt.
Show more (+2)

Psychotic sign/sympt.

p.*242Tyrext*89: het

No

♀

C

n.a.

n.a.

38

Yes

-Motor
Headache

n.a.

p.Met1?: het

No

♂

C

SRB

n.a.

n.a.

Yes

Brain calcification
Athetosis
Chorea
-Motor
Dyskinesia
NMS parkinsonism
Anxiety
Show more (+4)

Dyskinesia

p.Gln145*: het

No

♂

C

SRB

44

47

Yes

Brain calcification
-Motor
Dyskinesia
Tremor (any or unspecified)
Show more (+1)

Dyskinesia

p.Gln145*: het

No

♀

C

SRB

42

43

Yes

-Motor
Cerebellar signs
Depression
Dyskinesia
Cognitive decline
Chorea
NMS parkinsonism
Brain calcification
Anxiety
Show more (+6)

Anxiety

p.Gln145*: het

Yes

♀

C

n.a.

16

30

Yes

Migraine (any subclass)
Tremor (any or unspecified)
Parkinsonism
PKD
Cognitive decline
Chorea
Speech disturbance
-Motor
Brain calcification
Depression
Headache
Show more (+8)

Migraine (any subclass)

p.Leu9Arg: het

No

♀

C

n.a.

n.a.

15

Yes

Headache
Brain calcification
Migraine (any subclass)
Cognitive decline
Dystonia
-Motor
Show more (+3)

n.a.

p.Met1?: het

Yes

♀

C

n.a.

n.a.

34

Yes

Dystonia
Headache
Brain calcification
-Motor
Show more (+1)

n.a.

p.Met1?: het

Yes

♂

C

SRB

36

41

Yes

Ataxia
Depression
NMS parkinsonism
Parkinsonism
Cognitive decline
-Motor
Brain calcification
Psychotic sign/sympt.
Dyskinesia
Show more (+6)

Ataxia

p.Gln145*: het

No

♀

C

SRB

45

54

Yes

Brain calcification
-Motor
Chorea
Speech disturbance
Show more (+1)

n.a.

p.Gln145*: het

No

♂

C

n.a.

13

56

Yes

Brain calcification
NMS parkinsonism
Cerebellar signs
Ataxia
Headache
-Motor
Parkinsonism
Migraine (any subclass)
Postural tremor
Tremor (any or unspecified)
Depression
Show more (+8)

Migraine (any subclass)

p.Leu9Arg: het

Yes

♀

C

FRA

n.a.

26

Yes

Parkinsonism
Brain calcification
Cognitive decline
Dyskinesia
Psychotic sign/sympt.
-Motor
NMS parkinsonism
Dystonia
Show more (+5)

Psychotic sign/sympt.

p.*242Tyrext*89: het

No

♂

C

n.a.

12

21

Yes

Cerebellar signs
Parkinsonism
NMS parkinsonism
Tremor (any or unspecified)
Rigidity
Ataxia
Tremor, action
Bradykinesia
-Motor
Brain calcification
Postural tremor
Cognitive decline
Chorea
Show more (+10)

n.a.

p.Leu9Arg: het

No

♀

C

n.a.

14

26

Yes

NMS parkinsonism
Parkinsonism
Brain calcification
Postural tremor
Cognitive decline
Headache
Cerebellar signs
Chorea
PKD
Tremor (any or unspecified)
Migraine (any subclass)
-Motor
Show more (+9)

Migraine (any subclass)

p.Leu9Arg: het