Taghavi, 2017: Overview of all reported PARK-Parkin patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
n.a.
|
IRN
|
19
|
23
|
Yes
|
Bradykinesia
Parkinsonism Atypical parkinsonism Rigidity Autonomic sign/sympt. Tremor at rest -Motor Tremor, action Dystonia Show more (+6) |
Tremor at rest
|
|
Yes
|
♀
|
n.a.
|
IRN
|
27
|
42
|
Yes
|
Autonomic sign/sympt.
-Motor Cognitive decline Sleep disorder Parkinsonism Tremor at rest Bradykinesia NMS parkinsonism Postural instability Show more (+6) |
Tremor at rest
|
|
No
|
♂
|
n.a.
|
IRN
|
30
|
33
|
Yes
|
Tremor at rest
|
||
No
|
♂
|
n.a.
|
IRN
|
12
|
30
|
Yes
|
Tremor at rest
Dystonia Rigidity Olfactory impairment Postural instability Parkinsonism -Motor Bradykinesia Show more (+5) |
Bradykinesia
|
|
No
|
♀
|
n.a.
|
IRN
|
17
|
37
|
Yes
|
Tremor at rest
-Motor Bradykinesia Sleep disorder Tremor, action Postural instability Cognitive decline Parkinsonism Show more (+5) |
Tremor at rest
|
|
Yes
|
♀
|
n.a.
|
IRN
|
34
|
42
|
Yes
|
Rigidity
Parkinsonism Tremor, action Atypical parkinsonism Autonomic sign/sympt. -Motor Tremor at rest Postural instability Show more (+5) |
Tremor at rest
|
|
No
|
♀
|
n.a.
|
IRN
|
32
|
45
|
Yes
|
Rigidity
|
||
No
|
♂
|
n.a.
|
IRN
|
24
|
34
|
Yes
|
Atypical parkinsonism
Sleep disorder Postural instability -Motor Olfactory impairment Autonomic sign/sympt. NMS parkinsonism Parkinsonism Rigidity Bradykinesia Tremor at rest Show more (+8) |
Tremor at rest
|
|
No
|
♀
|
n.a.
|
IRN
|
23
|
35
|
Yes
|
Rigidity
Atypical parkinsonism Cognitive decline Autonomic sign/sympt. Tremor at rest Bradykinesia Postural instability -Motor Parkinsonism Show more (+6) |
Tremor at rest
|
|
Yes
|
♂
|
n.a.
|
IRN
|
23
|
52
|
Yes
|
Bradykinesia
|
||
No
|
♀
|
n.a.
|
IRN
|
40
|
54
|
Yes
|
Postural instability
Autonomic sign/sympt. Bradykinesia Tremor at rest -Motor Parkinsonism Rigidity Show more (+4) |
Tremor at rest
|
|
No
|
♂
|
n.a.
|
IRN
|
20
|
49
|
Yes
|
Postural instability
Sleep disorder Parkinsonism Tremor (any or unspecified) NMS parkinsonism Atypical parkinsonism -Motor Tremor, action Cognitive decline Olfactory impairment Rigidity Autonomic sign/sympt. Tremor at rest Show more (+10) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
IRN
|
14
|
28
|
Yes
|
Dystonia
Parkinsonism Olfactory impairment Rigidity Bradykinesia Tremor at rest Postural instability -Motor Show more (+5) |
Bradykinesia
|
|
Yes
|
♂
|
n.a.
|
IRN
|
22
|
41
|
Yes
|
Postural instability
Rigidity Atypical parkinsonism -Motor Autonomic sign/sympt. NMS parkinsonism Depression Dyskinesia Motor fluctuations Bradykinesia Tremor at rest Sleep disorder Parkinsonism Olfactory impairment Show more (+11) |
Bradykinesia
|
|
No
|
♀
|
n.a.
|
IRN
|
35
|
38
|
Yes
|
Autonomic sign/sympt.
Bradykinesia Olfactory impairment Postural instability Rigidity Atypical parkinsonism Parkinsonism Tremor at rest -Motor Sleep disorder NMS parkinsonism Show more (+8) |
Tremor at rest
|
|
No
|
♀
|
n.a.
|
IRN
|
27
|
42
|
Yes
|
Parkinsonism
Sleep disorder NMS parkinsonism Tremor at rest -Motor Tremor, action Autonomic sign/sympt. Postural instability Show more (+5) |
Tremor at rest
|
|
Yes
|
♂
|
n.a.
|
IRN
|
24
|
29
|
Yes
|
Tremor at rest
|
||
No
|
♂
|
n.a.
|
IRN
|
27
|
60
|
Yes
|
Atypical parkinsonism
Rigidity Postural instability Tremor at rest Sleep disorder -Motor Bradykinesia Olfactory impairment Autonomic sign/sympt. NMS parkinsonism Parkinsonism Show more (+8) |
Tremor at rest
|
|
Yes
|
♂
|
n.a.
|
IRN
|
14
|
35
|
Yes
|
Parkinsonism
Dystonia Bradykinesia -Motor Tremor at rest Rigidity Postural instability Show more (+4) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
IRN
|
45
|
50
|
Yes
|
Postural instability
Parkinsonism Sleep disorder Tremor at rest Rigidity Dystonia -Motor Show more (+4) |
Tremor at rest
|
|
Yes
|
♀
|
n.a.
|
IRN
|
27
|
32
|
Yes
|
Tremor at rest
|
||
Yes
|
♀
|
n.a.
|
IRN
|
14
|
42
|
Yes
|
-Motor
Bradykinesia Parkinsonism Postural instability Rigidity Tremor at rest Dystonia Show more (+4) |
Tremor at rest
|
|
No
|
♂
|
n.a.
|
IRN
|
24
|
48
|
Yes
|
NMS parkinsonism
Postural instability Tremor, action Sleep disorder Psychotic sign/sympt. -Motor Atypical parkinsonism Cognitive decline Dystonia Rigidity Anxiety Bradykinesia Parkinsonism Olfactory impairment Autonomic sign/sympt. Show more (+12) |
Bradykinesia
|
|
Yes
|
♂
|
n.a.
|
IRN
|
44
|
47
|
Yes
|
Atypical parkinsonism
Sleep disorder Postural instability Tremor at rest Rigidity Autonomic sign/sympt. Cognitive decline Parkinsonism NMS parkinsonism -Motor Bradykinesia Show more (+8) |
Tremor at rest
|
|
No
|
♂
|
n.a.
|
IRN
|
21
|
42
|
Yes
|
-Motor
Tremor, action Parkinsonism Olfactory impairment NMS parkinsonism Postural instability Bradykinesia Rigidity Autonomic sign/sympt. Atypical parkinsonism Sleep disorder Tremor at rest Show more (+9) |
Tremor at rest
|
|
Yes
|
♂
|
n.a.
|
IRN
|
13
|
62
|
Yes
|
Dystonia
Parkinsonism Bradykinesia Olfactory impairment Autonomic sign/sympt. Atypical parkinsonism -Motor Postural instability Tremor at rest Rigidity NMS parkinsonism Tremor, action Show more (+9) |
Tremor at rest
|
|
Yes
|
♂
|
n.a.
|
IRN
|
23
|
30
|
Yes
|
-Motor
NMS parkinsonism Tremor at rest Parkinsonism Postural instability Sleep disorder Autonomic sign/sympt. Olfactory impairment Atypical parkinsonism Rigidity Bradykinesia Show more (+8) |
Tremor at rest
|
|
No
|
♂
|
n.a.
|
IRN
|
24
|
47
|
Yes
|
Tremor at rest
|
||
No
|
♂
|
n.a.
|
IRN
|
13
|
50
|
Yes
|
Parkinsonism
Tremor at rest Bradykinesia Postural instability -Motor Tremor, action Rigidity Show more (+4) |
n.a.
|
|
No
|
♀
|
n.a.
|
IRN
|
45
|
52
|
Yes
|
Tremor at rest
Bradykinesia Rigidity -Motor Postural instability Dystonia Parkinsonism Show more (+4) |
Tremor at rest
|
|
No
|
♂
|
n.a.
|
IRN
|
37
|
44
|
Yes
|
Dystonic tremor
-Motor Parkinsonism Motor fluctuations Postural instability Bradykinesia Rigidity Dystonia Show more (+5) |
n.a.
|
|
No
|
♂
|
n.a.
|
IRN
|
15
|
46
|
Yes
|
Parkinsonism
Rigidity -Motor Dystonia Postural instability Bradykinesia Tremor at rest Show more (+4) |
Bradykinesia
|
|
No
|
♂
|
n.a.
|
IRN
|
13
|
54
|
Yes
|
Tremor at rest
|
||
Yes
|
♂
|
n.a.
|
IRN
|
30
|
38
|
Yes
|
Postural instability
-Motor Atypical parkinsonism Parkinsonism Autonomic sign/sympt. NMS parkinsonism Tremor, action Tremor at rest Olfactory impairment Bradykinesia Sleep disorder Show more (+8) |
Tremor at rest
|
|
Yes
|
♀
|
n.a.
|
IRN
|
25
|
35
|
Yes
|
Cognitive decline
Tremor, action Postural instability Tremor at rest Olfactory impairment Dystonia Atypical parkinsonism Sleep disorder NMS parkinsonism Psychotic sign/sympt. Rigidity -Motor Autonomic sign/sympt. Bradykinesia Parkinsonism Show more (+12) |
Tremor at rest
|
|
No
|
♀
|
n.a.
|
IRN
|
35
|
45
|
Yes
|
Tremor at rest
|
||
No
|
♂
|
n.a.
|
IRN
|
22
|
40
|
Yes
|
Dyskinesia
Psychotic sign/sympt. Parkinsonism -Motor Sleep disorder Bradykinesia Anxiety Show more (+4) |
n.a.
|
|
No
|
♂
|
n.a.
|
IRN
|
15
|
32
|
Yes
|
-Motor
Olfactory impairment Autonomic sign/sympt. NMS parkinsonism Postural instability Tremor at rest Rigidity Bradykinesia Dystonia Parkinsonism Show more (+7) |
Tremor at rest
|
|
Yes
|
♂
|
n.a.
|
IRN
|
35
|
47
|
Yes
|
Bradykinesia
Postural instability Parkinsonism Rigidity Tremor at rest Sleep disorder Psychotic sign/sympt. -Motor Show more (+5) |
Tremor at rest
|
|
Yes
|
♀
|
n.a.
|
IRN
|
28
|
31
|
Yes
|
Tremor, action
-Motor Cognitive decline Tremor at rest Autonomic sign/sympt. Parkinsonism Show more (+3) |
Tremor at rest
|