Marongiu, 2006: Overview of all reported PARK-LRRK2 patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
n.a.
|
ITA
|
40
|
41
|
No
|
Anxiety
-Motor Rigidity Parkinsonism Bradykinesia Tremor at rest Tremor (any or unspecified) NMS parkinsonism Show more (+5) |
Rigidity
|
|
Yes
|
♀
|
n.a.
|
ITA
|
78
|
81
|
Yes
|
Rigidity
Tremor at rest Tremor (any or unspecified) Dyskinesia Parkinsonism Cognitive decline -Motor Bradykinesia Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
58
|
69
|
No
|
Rigidity
|
||
Yes
|
♀
|
n.a.
|
ITA
|
55
|
75
|
Yes
|
Dyskinesia
Bradykinesia -Motor Rigidity Motor fluctuations NMS parkinsonism Parkinsonism Show more (+4) |
Rigidity
|
|
Yes
|
♂
|
n.a.
|
ITA
|
58
|
78
|
No
|
Tremor at rest
Motor fluctuations -Motor Parkinsonism Rigidity Dyskinesia Bradykinesia Tremor (any or unspecified) Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
57
|
65
|
Yes
|
Tremor (any or unspecified)
Bradykinesia Rigidity NMS parkinsonism -Motor Motor fluctuations Tremor at rest Parkinsonism Autonomic sign/sympt. Dyskinesia Show more (+7) |
Rigidity
|
|
Yes
|
♀
|
n.a.
|
ITA
|
54
|
60
|
Yes
|
Autonomic sign/sympt.
Depression Parkinsonism NMS parkinsonism Tremor at rest -Motor Tremor (any or unspecified) Rigidity Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
35
|
40
|
No
|
Bradykinesia
|
||
Yes
|
♂
|
n.a.
|
ITA
|
39
|
44
|
No
|
Bradykinesia
Tremor (any or unspecified) NMS parkinsonism Parkinsonism Hyperreflexia Rigidity Anxiety Tremor at rest Dyskinesia -Motor Show more (+7) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
47
|
60
|
No
|
Depression
-Motor Parkinsonism Tremor (any or unspecified) Tremor at rest Bradykinesia NMS parkinsonism Rigidity Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
63
|
71
|
Yes
|
Anxiety
-Motor Motor fluctuations Bradykinesia NMS parkinsonism Depression Parkinsonism Rigidity Show more (+5) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
42
|
52
|
No
|
Parkinsonism
Rigidity Dyskinesia NMS parkinsonism Motor fluctuations Bradykinesia Depression -Motor Show more (+5) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
46
|
54
|
Yes
|
Tremor at rest
Tremor (any or unspecified) Parkinsonism Bradykinesia Hyperreflexia Rigidity -Motor Show more (+4) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
71
|
84
|
Yes
|
Anxiety
Tremor (any or unspecified) Tremor at rest NMS parkinsonism Hyperreflexia Parkinsonism Cognitive decline Depression -Motor Bradykinesia Show more (+7) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
61
|
73
|
No
|
Parkinsonism
Bradykinesia Dyskinesia Depression Tremor (any or unspecified) NMS parkinsonism Tremor at rest Rigidity -Motor Motor fluctuations Show more (+7) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
71
|
81
|
Yes
|
Rigidity
|
||
Yes
|
♂
|
n.a.
|
ITA
|
70
|
75
|
No
|
Parkinsonism
-Motor Depression NMS parkinsonism Bradykinesia Tremor (any or unspecified) Rigidity Tremor at rest Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
59
|
65
|
Yes
|
Parkinsonism
Tremor (any or unspecified) Bradykinesia -Motor Motor fluctuations Tremor at rest Rigidity Show more (+4) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
44
|
57
|
No
|
Autonomic sign/sympt.
NMS parkinsonism Depression Rigidity Motor fluctuations Parkinsonism Bradykinesia -Motor Anxiety Dyskinesia Show more (+7) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
52
|
60
|
No
|
Anxiety
Hyperreflexia Parkinsonism Tremor at rest Rigidity Tremor (any or unspecified) -Motor Dyskinesia Bradykinesia NMS parkinsonism Show more (+7) |
Bradykinesia
|
|
Yes
|
♂
|
n.a.
|
ITA
|
43
|
46
|
Yes
|
Bradykinesia
|