Marongiu, 2006: Overview of all reported PARK-LRRK2 patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
n.a.
|
ITA
|
40
|
41
|
No
|
Rigidity
Tremor at rest Tremor (any or unspecified) Bradykinesia NMS parkinsonism -Motor Parkinsonism Anxiety Show more (+5) |
Rigidity
|
|
Yes
|
♀
|
n.a.
|
ITA
|
78
|
81
|
Yes
|
Tremor at rest
Cognitive decline Bradykinesia Dyskinesia Rigidity Parkinsonism -Motor Tremor (any or unspecified) Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
58
|
69
|
No
|
Rigidity
|
||
Yes
|
♀
|
n.a.
|
ITA
|
55
|
75
|
Yes
|
Dyskinesia
Bradykinesia -Motor NMS parkinsonism Parkinsonism Motor fluctuations Rigidity Show more (+4) |
Rigidity
|
|
Yes
|
♂
|
n.a.
|
ITA
|
58
|
78
|
No
|
Motor fluctuations
Tremor at rest Tremor (any or unspecified) Bradykinesia Parkinsonism Rigidity Dyskinesia -Motor Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
57
|
65
|
Yes
|
Tremor (any or unspecified)
Rigidity Bradykinesia Autonomic sign/sympt. -Motor NMS parkinsonism Tremor at rest Parkinsonism Dyskinesia Motor fluctuations Show more (+7) |
Rigidity
|
|
Yes
|
♀
|
n.a.
|
ITA
|
54
|
60
|
Yes
|
Rigidity
Tremor at rest -Motor Tremor (any or unspecified) Autonomic sign/sympt. Parkinsonism NMS parkinsonism Depression Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
35
|
40
|
No
|
Bradykinesia
|
||
Yes
|
♂
|
n.a.
|
ITA
|
39
|
44
|
No
|
Hyperreflexia
Parkinsonism Anxiety Rigidity -Motor Tremor at rest Tremor (any or unspecified) Bradykinesia NMS parkinsonism Dyskinesia Show more (+7) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
47
|
60
|
No
|
Rigidity
Tremor at rest NMS parkinsonism Parkinsonism Tremor (any or unspecified) Depression Bradykinesia -Motor Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
63
|
71
|
Yes
|
Depression
Bradykinesia -Motor NMS parkinsonism Motor fluctuations Anxiety Parkinsonism Rigidity Show more (+5) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
42
|
52
|
No
|
Bradykinesia
NMS parkinsonism Parkinsonism Depression Dyskinesia Motor fluctuations Rigidity -Motor Show more (+5) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
46
|
54
|
Yes
|
-Motor
Tremor (any or unspecified) Hyperreflexia Parkinsonism Rigidity Bradykinesia Tremor at rest Show more (+4) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
71
|
84
|
Yes
|
Hyperreflexia
-Motor Tremor (any or unspecified) Anxiety Parkinsonism Tremor at rest Cognitive decline Depression NMS parkinsonism Bradykinesia Show more (+7) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
61
|
73
|
No
|
NMS parkinsonism
-Motor Depression Tremor (any or unspecified) Dyskinesia Tremor at rest Bradykinesia Motor fluctuations Parkinsonism Rigidity Show more (+7) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
71
|
81
|
Yes
|
Rigidity
|
||
Yes
|
♂
|
n.a.
|
ITA
|
70
|
75
|
No
|
Tremor at rest
-Motor Rigidity Depression Parkinsonism Bradykinesia NMS parkinsonism Tremor (any or unspecified) Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
59
|
65
|
Yes
|
Tremor at rest
Rigidity Motor fluctuations Parkinsonism Bradykinesia -Motor Tremor (any or unspecified) Show more (+4) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
44
|
57
|
No
|
Bradykinesia
NMS parkinsonism Rigidity Motor fluctuations Dyskinesia -Motor Anxiety Parkinsonism Autonomic sign/sympt. Depression Show more (+7) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
52
|
60
|
No
|
Hyperreflexia
Tremor (any or unspecified) Rigidity -Motor Bradykinesia Dyskinesia NMS parkinsonism Anxiety Parkinsonism Tremor at rest Show more (+7) |
Bradykinesia
|
|
Yes
|
♂
|
n.a.
|
ITA
|
43
|
46
|
Yes
|
Bradykinesia
|