Marongiu, 2006: Overview of all reported PARK-LRRK2 patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
n.a.
|
ITA
|
40
|
41
|
No
|
NMS parkinsonism
Tremor at rest -Motor Bradykinesia Rigidity Anxiety Parkinsonism Tremor (any or unspecified) Show more (+5) |
Rigidity
|
|
Yes
|
♀
|
n.a.
|
ITA
|
78
|
81
|
Yes
|
Tremor (any or unspecified)
-Motor Parkinsonism Bradykinesia Cognitive decline Dyskinesia Rigidity Tremor at rest Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
58
|
69
|
No
|
Rigidity
|
||
Yes
|
♀
|
n.a.
|
ITA
|
55
|
75
|
Yes
|
NMS parkinsonism
Bradykinesia Motor fluctuations Parkinsonism Dyskinesia -Motor Rigidity Show more (+4) |
Rigidity
|
|
Yes
|
♂
|
n.a.
|
ITA
|
58
|
78
|
No
|
Tremor at rest
Tremor (any or unspecified) Motor fluctuations Bradykinesia Parkinsonism Dyskinesia Rigidity -Motor Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
57
|
65
|
Yes
|
-Motor
NMS parkinsonism Parkinsonism Tremor (any or unspecified) Motor fluctuations Dyskinesia Tremor at rest Bradykinesia Autonomic sign/sympt. Rigidity Show more (+7) |
Rigidity
|
|
Yes
|
♀
|
n.a.
|
ITA
|
54
|
60
|
Yes
|
Tremor at rest
NMS parkinsonism -Motor Autonomic sign/sympt. Rigidity Tremor (any or unspecified) Parkinsonism Depression Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
35
|
40
|
No
|
Bradykinesia
|
||
Yes
|
♂
|
n.a.
|
ITA
|
39
|
44
|
No
|
-Motor
Tremor (any or unspecified) Hyperreflexia Bradykinesia Tremor at rest Parkinsonism Anxiety Dyskinesia Rigidity NMS parkinsonism Show more (+7) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
47
|
60
|
No
|
Bradykinesia
Depression Tremor (any or unspecified) Tremor at rest -Motor NMS parkinsonism Parkinsonism Rigidity Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
63
|
71
|
Yes
|
Motor fluctuations
Parkinsonism Anxiety Bradykinesia Depression -Motor NMS parkinsonism Rigidity Show more (+5) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
42
|
52
|
No
|
Motor fluctuations
-Motor Bradykinesia NMS parkinsonism Parkinsonism Rigidity Dyskinesia Depression Show more (+5) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
46
|
54
|
Yes
|
Parkinsonism
-Motor Tremor (any or unspecified) Hyperreflexia Bradykinesia Tremor at rest Rigidity Show more (+4) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
71
|
84
|
Yes
|
NMS parkinsonism
Depression Tremor (any or unspecified) Tremor at rest Hyperreflexia -Motor Anxiety Bradykinesia Cognitive decline Parkinsonism Show more (+7) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
61
|
73
|
No
|
Depression
Tremor at rest Dyskinesia Parkinsonism Motor fluctuations NMS parkinsonism Tremor (any or unspecified) -Motor Rigidity Bradykinesia Show more (+7) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
n.a.
|
ITA
|
71
|
81
|
Yes
|
Rigidity
|
||
Yes
|
♂
|
n.a.
|
ITA
|
70
|
75
|
No
|
Parkinsonism
Depression Rigidity Tremor at rest NMS parkinsonism Tremor (any or unspecified) -Motor Bradykinesia Show more (+5) |
Tremor (any or unspecified)
|
|
Yes
|
♀
|
n.a.
|
ITA
|
59
|
65
|
Yes
|
Bradykinesia
-Motor Tremor at rest Tremor (any or unspecified) Motor fluctuations Rigidity Parkinsonism Show more (+4) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
44
|
57
|
No
|
Parkinsonism
Dyskinesia Anxiety NMS parkinsonism -Motor Bradykinesia Autonomic sign/sympt. Depression Motor fluctuations Rigidity Show more (+7) |
Bradykinesia
|
|
Yes
|
♀
|
n.a.
|
ITA
|
52
|
60
|
No
|
Bradykinesia
NMS parkinsonism -Motor Tremor (any or unspecified) Anxiety Hyperreflexia Parkinsonism Rigidity Dyskinesia Tremor at rest Show more (+7) |
Bradykinesia
|
|
Yes
|
♂
|
n.a.
|
ITA
|
43
|
46
|
Yes
|
Bradykinesia
|