Marongiu, 2006: Overview of all reported PARK-LRRK2 patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
n.a.
ITA
40
41
No
Rigidity
Anxiety
Parkinsonism
Tremor (any or unspecified)
Bradykinesia
-Motor
NMS parkinsonism
Tremor at rest
Show more (+5)
Rigidity
Gly2019Ser: het
Yes
n.a.
ITA
78
81
Yes
Tremor at rest
-Motor
Parkinsonism
Cognitive decline
Dyskinesia
Tremor (any or unspecified)
Rigidity
Bradykinesia
Show more (+5)
Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
58
69
No
Hyperreflexia
-Motor
Bradykinesia
Rigidity
Parkinsonism
Show more (+2)
Rigidity
Gly2019Ser: het
Yes
n.a.
ITA
55
75
Yes
NMS parkinsonism
Dyskinesia
Motor fluctuations
Rigidity
Bradykinesia
Parkinsonism
-Motor
Show more (+4)
Rigidity
Gly2019Ser: het
Yes
n.a.
ITA
58
78
No
Motor fluctuations
-Motor
Parkinsonism
Tremor (any or unspecified)
Dyskinesia
Bradykinesia
Tremor at rest
Rigidity
Show more (+5)
Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
57
65
Yes
Motor fluctuations
NMS parkinsonism
Tremor at rest
Rigidity
Autonomic sign/sympt.
Dyskinesia
Tremor (any or unspecified)
-Motor
Parkinsonism
Bradykinesia
Show more (+7)
Rigidity
Gly2019Ser: het
Yes
n.a.
ITA
54
60
Yes
Tremor at rest
NMS parkinsonism
Parkinsonism
Tremor (any or unspecified)
-Motor
Autonomic sign/sympt.
Depression
Rigidity
Show more (+5)
Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
35
40
No
-Motor
Rigidity
Hyperreflexia
Parkinsonism
Bradykinesia
Show more (+2)
Bradykinesia
Gly2019Ser: het
Yes
n.a.
ITA
39
44
No
Tremor (any or unspecified)
-Motor
NMS parkinsonism
Anxiety
Parkinsonism
Rigidity
Tremor at rest
Dyskinesia
Hyperreflexia
Bradykinesia
Show more (+7)
Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
47
60
No
NMS parkinsonism
Bradykinesia
Tremor (any or unspecified)
Depression
-Motor
Parkinsonism
Tremor at rest
Rigidity
Show more (+5)
Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
63
71
Yes
Bradykinesia
Motor fluctuations
NMS parkinsonism
Parkinsonism
Rigidity
-Motor
Anxiety
Depression
Show more (+5)
Bradykinesia
Gly2019Ser: het
Yes
n.a.
ITA
42
52
No
Bradykinesia
Depression
Parkinsonism
NMS parkinsonism
-Motor
Motor fluctuations
Dyskinesia
Rigidity
Show more (+5)
Bradykinesia
Gly2019Ser: het
Yes
n.a.
ITA
46
54
Yes
Bradykinesia
Tremor (any or unspecified)
Hyperreflexia
Rigidity
Tremor at rest
Parkinsonism
-Motor
Show more (+4)
Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
71
84
Yes
-Motor
Bradykinesia
Depression
Tremor (any or unspecified)
Parkinsonism
Anxiety
Cognitive decline
Hyperreflexia
NMS parkinsonism
Tremor at rest
Show more (+7)
Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
61
73
No
Tremor at rest
Depression
Dyskinesia
Bradykinesia
Rigidity
-Motor
Tremor (any or unspecified)
NMS parkinsonism
Motor fluctuations
Parkinsonism
Show more (+7)
Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
71
81
Yes
Parkinsonism
Rigidity
Tremor at rest
Bradykinesia
Tremor (any or unspecified)
-Motor
Show more (+3)
Rigidity
Gly2019Ser: het
Yes
n.a.
ITA
70
75
No
Parkinsonism
Bradykinesia
Depression
-Motor
Rigidity
Tremor at rest
Tremor (any or unspecified)
NMS parkinsonism
Show more (+5)
Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
59
65
Yes
Motor fluctuations
Tremor at rest
Tremor (any or unspecified)
Parkinsonism
Bradykinesia
Rigidity
-Motor
Show more (+4)
Bradykinesia
Gly2019Ser: het
Yes
n.a.
ITA
44
57
No
-Motor
Depression
Autonomic sign/sympt.
Anxiety
Rigidity
Dyskinesia
Parkinsonism
Motor fluctuations
Bradykinesia
NMS parkinsonism
Show more (+7)
Bradykinesia
Gly2019Ser: het
Yes
n.a.
ITA
52
60
No
Bradykinesia
Dyskinesia
Anxiety
Rigidity
Tremor (any or unspecified)
Tremor at rest
Hyperreflexia
-Motor
NMS parkinsonism
Parkinsonism
Show more (+7)
Bradykinesia
Gly2019Ser: het
Yes
n.a.
ITA
43
46
Yes
-Motor
Bradykinesia
Parkinsonism
Rigidity
Show more (+1)
Bradykinesia
Gly2019Ser: het