Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Hyperreflexia in upper limbs
Spasticity, lower limb Spastic gait Impaired vibratory sensation -Pure or uncomplicated Lower limb muscle weakness Abnormality of the bladder Walking aids -Lower limb amyotrophy Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
Spastic gait
Babinski sign -Pure or uncomplicated Walking aids Spasticity, lower limb Abnormality of the bladder Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
Babinski sign
-Lower limb amyotrophy -Pure or uncomplicated Lower limb muscle weakness Spasticity, lower limb Impaired vibratory sensation Spastic gait Abnormality of the bladder Hyperreflexia in upper limbs Walking aids Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Babinski sign
Muscle weakness, upper limb Lower limb muscle weakness Spastic gait Hyperreflexia in upper limbs Wheelchair Walking aids Spasticity, lower limb -Pure or uncomplicated Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Hyperreflexia in upper limbs
Spasticity, lower limb Babinski sign Lower limb muscle weakness Spastic gait Abnormality of the bladder Wheelchair Muscle weakness, upper limb Impaired vibratory sensation Walking aids Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Hyperreflexia in upper limbs
Spasticity, lower limb Walking aids Impaired vibratory sensation Spastic gait Lower limb muscle weakness -Pure or uncomplicated Abnormality of the bladder Babinski sign Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
Hyperreflexia in upper limbs
Spasticity, lower limb Impaired vibratory sensation Babinski sign Abnormality of the bladder Spastic gait Walking aids Lower limb muscle weakness -Pure or uncomplicated Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
Spasticity, lower limb
-Pure or uncomplicated Spastic gait Hyperreflexia in upper limbs Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Babinski sign
Lower limb muscle weakness Walking aids Ataxia, limb Spasticity, upper limb Spasticity, lower limb Spastic gait Abnormality of the bladder Hyperreflexia in upper limbs Impaired vibratory sensation Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
Spastic gait
Babinski sign -Pure or uncomplicated Lower limb muscle weakness Hyperreflexia in upper limbs -Lower limb amyotrophy Spasticity, lower limb Walking aids Show more (+5) |
n.a.
|