Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Impaired vibratory sensation
Hyperreflexia in upper limbs Lower limb muscle weakness Walking aids -Pure or uncomplicated Abnormality of the bladder Spasticity, lower limb -Lower limb amyotrophy Spastic gait Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
Spastic gait
Abnormality of the bladder Spasticity, lower limb Walking aids Babinski sign -Pure or uncomplicated Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
Spasticity, lower limb
Impaired vibratory sensation -Pure or uncomplicated Spastic gait -Lower limb amyotrophy Hyperreflexia in upper limbs Babinski sign Lower limb muscle weakness Walking aids Abnormality of the bladder Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Lower limb muscle weakness
Babinski sign Muscle weakness, upper limb Spastic gait -Pure or uncomplicated Hyperreflexia in upper limbs Walking aids Wheelchair Spasticity, lower limb Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Walking aids
Muscle weakness, upper limb Hyperreflexia in upper limbs Wheelchair Impaired vibratory sensation Babinski sign Spastic gait Lower limb muscle weakness Abnormality of the bladder Spasticity, lower limb Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Spastic gait
Walking aids Abnormality of the bladder Spasticity, lower limb -Pure or uncomplicated Impaired vibratory sensation Hyperreflexia in upper limbs Lower limb muscle weakness Babinski sign Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
Walking aids
Spastic gait Impaired vibratory sensation Abnormality of the bladder -Pure or uncomplicated Spasticity, lower limb Lower limb muscle weakness Hyperreflexia in upper limbs Babinski sign Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
Hyperreflexia in upper limbs
-Pure or uncomplicated Spastic gait Spasticity, lower limb Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Babinski sign
Spasticity, upper limb Lower limb muscle weakness Impaired vibratory sensation Spasticity, lower limb Spastic gait Walking aids Hyperreflexia in upper limbs Ataxia, limb Abnormality of the bladder Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
-Pure or uncomplicated
Spastic gait Walking aids Spasticity, lower limb Lower limb muscle weakness -Lower limb amyotrophy Hyperreflexia in upper limbs Babinski sign Show more (+5) |
n.a.
|