Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Walking aids
Spasticity, lower limb -Pure or uncomplicated Abnormality of the bladder Spastic gait Impaired vibratory sensation Hyperreflexia in upper limbs Lower limb muscle weakness -Lower limb amyotrophy Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
Spasticity, lower limb
Abnormality of the bladder -Pure or uncomplicated Walking aids Babinski sign Spastic gait Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
Spasticity, lower limb
-Pure or uncomplicated Babinski sign -Lower limb amyotrophy Lower limb muscle weakness Walking aids Hyperreflexia in upper limbs Spastic gait Impaired vibratory sensation Abnormality of the bladder Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Wheelchair
Spasticity, lower limb Lower limb muscle weakness Spastic gait Muscle weakness, upper limb Walking aids -Pure or uncomplicated Babinski sign Hyperreflexia in upper limbs Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Spastic gait
Babinski sign Hyperreflexia in upper limbs Muscle weakness, upper limb Lower limb muscle weakness Abnormality of the bladder Spasticity, lower limb Wheelchair Impaired vibratory sensation Walking aids Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Lower limb muscle weakness
Spastic gait Abnormality of the bladder -Pure or uncomplicated Spasticity, lower limb Walking aids Babinski sign Hyperreflexia in upper limbs Impaired vibratory sensation Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
Spasticity, lower limb
Hyperreflexia in upper limbs Babinski sign -Pure or uncomplicated Walking aids Spastic gait Impaired vibratory sensation Lower limb muscle weakness Abnormality of the bladder Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
-Pure or uncomplicated
Spasticity, lower limb Hyperreflexia in upper limbs Spastic gait Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Spasticity, upper limb
Babinski sign Hyperreflexia in upper limbs Walking aids Impaired vibratory sensation Lower limb muscle weakness Spasticity, lower limb Spastic gait Abnormality of the bladder Ataxia, limb Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
Babinski sign
-Lower limb amyotrophy -Pure or uncomplicated Hyperreflexia in upper limbs Spastic gait Lower limb muscle weakness Spasticity, lower limb Walking aids Show more (+5) |
n.a.
|