Vandebona, 2012: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
n.a.
O
AUS
25
n.a.
n.a.
Spasticity, lower limb
Impaired vibratory sensation
Abnormality of the bladder
-Lower limb amyotrophy
Spastic gait
Walking aids
-Pure or uncomplicated
Lower limb muscle weakness
Hyperreflexia in upper limbs
Show more (+6)
n.a.
Yes
n.a.
O
AUS
20
54
n.a.
Spastic gait
Spasticity, lower limb
Abnormality of the bladder
-Pure or uncomplicated
Walking aids
Babinski sign
Show more (+3)
n.a.
Yes
n.a.
O
AUS
4
73
n.a.
Impaired vibratory sensation
Hyperreflexia in upper limbs
Walking aids
Babinski sign
Spastic gait
Lower limb muscle weakness
Abnormality of the bladder
-Lower limb amyotrophy
Spasticity, lower limb
-Pure or uncomplicated
Show more (+7)
n.a.
p.Trp148*: het
Yes
n.a.
O
AUS
41
65
n.a.
Spastic gait
Lower limb muscle weakness
-Pure or uncomplicated
Walking aids
Wheelchair
Babinski sign
Muscle weakness, upper limb
Spasticity, lower limb
Hyperreflexia in upper limbs
Show more (+6)
n.a.
Yes
n.a.
O
AUS
2
48
n.a.
Muscle weakness, upper limb
Spasticity, lower limb
Wheelchair
Abnormality of the bladder
Impaired vibratory sensation
Walking aids
Lower limb muscle weakness
Babinski sign
Spastic gait
Hyperreflexia in upper limbs
Show more (+7)
n.a.
Yes
n.a.
O
AUS
2
60
n.a.
Babinski sign
Spasticity, lower limb
Abnormality of the bladder
Impaired vibratory sensation
Hyperreflexia in upper limbs
Lower limb muscle weakness
Walking aids
Spastic gait
-Pure or uncomplicated
Show more (+6)
n.a.
Yes
n.a.
O
AUS
n.a.
55
n.a.
Lower limb muscle weakness
Walking aids
Spastic gait
Impaired vibratory sensation
Spasticity, lower limb
-Pure or uncomplicated
Abnormality of the bladder
Hyperreflexia in upper limbs
Babinski sign
Show more (+6)
n.a.
Yes
n.a.
O
AUS
32
38
n.a.
Spastic gait
Spasticity, lower limb
-Pure or uncomplicated
Hyperreflexia in upper limbs
Show more (+1)
n.a.
Yes
n.a.
O
AUS
10
48
n.a.
Walking aids
Abnormality of the bladder
Babinski sign
Impaired vibratory sensation
Ataxia, limb
Spasticity, upper limb
Hyperreflexia in upper limbs
Spasticity, lower limb
Spastic gait
Lower limb muscle weakness
Show more (+7)
n.a.
Yes
n.a.
O
AUS
n.a.
n.a.
n.a.
Walking aids
Babinski sign
-Lower limb amyotrophy
Spastic gait
Lower limb muscle weakness
-Pure or uncomplicated
Hyperreflexia in upper limbs
Spasticity, lower limb
Show more (+5)
n.a.