Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Spasticity, lower limb
-Pure or uncomplicated Hyperreflexia in upper limbs Walking aids -Lower limb amyotrophy Spastic gait Lower limb muscle weakness Abnormality of the bladder Impaired vibratory sensation Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
Abnormality of the bladder
Spastic gait Walking aids Spasticity, lower limb -Pure or uncomplicated Babinski sign Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
Babinski sign
-Pure or uncomplicated Spasticity, lower limb Abnormality of the bladder Lower limb muscle weakness Hyperreflexia in upper limbs Impaired vibratory sensation -Lower limb amyotrophy Walking aids Spastic gait Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Spasticity, lower limb
Hyperreflexia in upper limbs -Pure or uncomplicated Spastic gait Muscle weakness, upper limb Lower limb muscle weakness Babinski sign Walking aids Wheelchair Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Abnormality of the bladder
Spastic gait Lower limb muscle weakness Wheelchair Walking aids Spasticity, lower limb Muscle weakness, upper limb Babinski sign Hyperreflexia in upper limbs Impaired vibratory sensation Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Babinski sign
Spasticity, lower limb Abnormality of the bladder Impaired vibratory sensation Spastic gait Hyperreflexia in upper limbs Lower limb muscle weakness Walking aids -Pure or uncomplicated Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
Hyperreflexia in upper limbs
Spasticity, lower limb Walking aids Babinski sign Impaired vibratory sensation -Pure or uncomplicated Lower limb muscle weakness Spastic gait Abnormality of the bladder Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
Hyperreflexia in upper limbs
Spastic gait Spasticity, lower limb -Pure or uncomplicated Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Ataxia, limb
Lower limb muscle weakness Babinski sign Impaired vibratory sensation Abnormality of the bladder Spasticity, lower limb Spastic gait Walking aids Hyperreflexia in upper limbs Spasticity, upper limb Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
Hyperreflexia in upper limbs
Walking aids -Lower limb amyotrophy -Pure or uncomplicated Babinski sign Lower limb muscle weakness Spastic gait Spasticity, lower limb Show more (+5) |
n.a.
|