Vandebona, 2012: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
O
|
AUS
|
25
|
n.a.
|
n.a.
|
Spasticity, lower limb
Spastic gait -Lower limb amyotrophy Lower limb muscle weakness Walking aids Abnormality of the bladder Hyperreflexia in upper limbs -Pure or uncomplicated Impaired vibratory sensation Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
20
|
54
|
n.a.
|
Babinski sign
-Pure or uncomplicated Spastic gait Spasticity, lower limb Abnormality of the bladder Walking aids Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
4
|
73
|
n.a.
|
Lower limb muscle weakness
Walking aids Babinski sign Abnormality of the bladder -Pure or uncomplicated Hyperreflexia in upper limbs Spasticity, lower limb -Lower limb amyotrophy Spastic gait Impaired vibratory sensation Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
41
|
65
|
n.a.
|
Spastic gait
Wheelchair Lower limb muscle weakness Babinski sign Spasticity, lower limb -Pure or uncomplicated Hyperreflexia in upper limbs Muscle weakness, upper limb Walking aids Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
48
|
n.a.
|
Walking aids
Muscle weakness, upper limb Abnormality of the bladder Spastic gait Hyperreflexia in upper limbs Impaired vibratory sensation Wheelchair Spasticity, lower limb Lower limb muscle weakness Babinski sign Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
2
|
60
|
n.a.
|
Abnormality of the bladder
Hyperreflexia in upper limbs Spastic gait -Pure or uncomplicated Impaired vibratory sensation Walking aids Lower limb muscle weakness Spasticity, lower limb Babinski sign Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
55
|
n.a.
|
-Pure or uncomplicated
Walking aids Spastic gait Spasticity, lower limb Lower limb muscle weakness Impaired vibratory sensation Abnormality of the bladder Hyperreflexia in upper limbs Babinski sign Show more (+6) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
32
|
38
|
n.a.
|
Spasticity, lower limb
-Pure or uncomplicated Spastic gait Hyperreflexia in upper limbs Show more (+1) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
10
|
48
|
n.a.
|
Spastic gait
Lower limb muscle weakness Ataxia, limb Spasticity, upper limb Hyperreflexia in upper limbs Abnormality of the bladder Impaired vibratory sensation Babinski sign Walking aids Spasticity, lower limb Show more (+7) |
n.a.
|
|
Yes
|
n.a.
|
O
|
AUS
|
n.a.
|
n.a.
|
n.a.
|
-Pure or uncomplicated
Spastic gait Walking aids Hyperreflexia in upper limbs Babinski sign Spasticity, lower limb -Lower limb amyotrophy Lower limb muscle weakness Show more (+5) |
n.a.
|