De, 2001: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
No
♀
n.a.
USA
40
n.a.
n.a.
n.a.
n.a.
Yes
♂
n.a.
USA
40
47
n.a.
Abnormality of the bladder
Babinski sign
Spasticity, lower limb
Hyperreflexia in upper limbs
Lower limb muscle weakness
-Pure or uncomplicated
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n.a.