Proukakis, 2002: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
n.a.
|
n.a.
|
16
|
47
|
No
|
n.a.
|
||
No
|
n.a.
|
n.a.
|
n.a.
|
30
|
71
|
No
|
Spasticity, lower limb
Lower limb muscle weakness Babinski sign Spastic gait Abnormality of the bladder Show more (+2) |
n.a.
|
|
No
|
n.a.
|
n.a.
|
GBR
|
27
|
56
|
No
|
n.a.
|
||
Yes
|
n.a.
|
n.a.
|
GBR
|
45
|
60
|
No
|
Abnormality of the bladder
Walking aids Spastic gait Lower limb muscle weakness Babinski sign Hyperreflexia in upper limbs Spasticity, lower limb Show more (+4) |
n.a.
|
|
No
|
n.a.
|
n.a.
|
GBR
|
25
|
43
|
No
|
Spasticity, lower limb
Babinski sign Impaired vibratory sensation Walking aids Spastic gait Show more (+2) |
n.a.
|
|
No
|
n.a.
|
n.a.
|
GBR
|
35
|
72
|
No
|
Hyperreflexia in upper limbs
Inability to walk Impaired vibratory sensation Lower limb muscle weakness Spastic gait Spasticity, lower limb Wheelchair Babinski sign Show more (+5) |
n.a.
|
|
No
|
n.a.
|
n.a.
|
n.a.
|
16
|
42
|
No
|
Lower limb muscle weakness
Spastic gait Spasticity, lower limb |
n.a.
|
|
No
|
n.a.
|
n.a.
|
n.a.
|
20
|
37
|
No
|
Lower limb muscle weakness
Spasticity, lower limb Spastic gait |
n.a.
|
|
No
|
n.a.
|
n.a.
|
GBR
|
40
|
63
|
No
|
Lower limb muscle weakness
Abnormality of the bladder Impaired vibratory sensation Hyperreflexia in upper limbs Spastic gait Spasticity, lower limb Ataxia, limb Wheelchair Nystagmus Babinski sign Show more (+7) |
n.a.
|
|
No
|
n.a.
|
n.a.
|
n.a.
|
35
|
40
|
No
|
Spasticity, lower limb
Spastic gait |
n.a.
|