Proukakis, 2002: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
n.a.
|
n.a.
|
n.a.
|
16
|
47
|
No
|
n.a.
|
||
No
|
n.a.
|
n.a.
|
n.a.
|
30
|
71
|
No
|
Spastic gait
Lower limb muscle weakness Babinski sign Abnormality of the bladder Spasticity, lower limb Show more (+2) |
n.a.
|
|
No
|
n.a.
|
n.a.
|
GBR
|
27
|
56
|
No
|
n.a.
|
||
Yes
|
n.a.
|
n.a.
|
GBR
|
45
|
60
|
No
|
Lower limb muscle weakness
Spasticity, lower limb Walking aids Hyperreflexia in upper limbs Babinski sign Spastic gait Abnormality of the bladder Show more (+4) |
n.a.
|
|
No
|
n.a.
|
n.a.
|
GBR
|
25
|
43
|
No
|
Walking aids
Spasticity, lower limb Babinski sign Spastic gait Impaired vibratory sensation Show more (+2) |
n.a.
|
|
No
|
n.a.
|
n.a.
|
GBR
|
35
|
72
|
No
|
Spastic gait
Hyperreflexia in upper limbs Spasticity, lower limb Lower limb muscle weakness Inability to walk Wheelchair Babinski sign Impaired vibratory sensation Show more (+5) |
n.a.
|
|
No
|
n.a.
|
n.a.
|
n.a.
|
16
|
42
|
No
|
Lower limb muscle weakness
Spasticity, lower limb Spastic gait |
n.a.
|
|
No
|
n.a.
|
n.a.
|
n.a.
|
20
|
37
|
No
|
Spasticity, lower limb
Spastic gait Lower limb muscle weakness |
n.a.
|
|
No
|
n.a.
|
n.a.
|
GBR
|
40
|
63
|
No
|
Wheelchair
Nystagmus Hyperreflexia in upper limbs Spasticity, lower limb Abnormality of the bladder Babinski sign Lower limb muscle weakness Ataxia, limb Spastic gait Impaired vibratory sensation Show more (+7) |
n.a.
|
|
No
|
n.a.
|
n.a.
|
n.a.
|
35
|
40
|
No
|
Spasticity, lower limb
Spastic gait |
n.a.
|