Orlacchio, 2005: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
C
ITA
25
46
n.a.
Spasticity, lower limb
Pes cavus
Central motor conduction time abnormality
Spastic gait
Babinski sign
Impaired vibratory sensation
Show more (+3)
n.a.
No
C
ITA
23
41
n.a.
Spasticity, lower limb
Spastic gait
Impaired vibratory sensation
Pes cavus
Central motor conduction time abnormality
Abnormality of the bladder
Babinski sign
Show more (+4)
n.a.
No
C
ITA
49
75
n.a.
Spastic gait
Abnormality of the bladder
Central motor conduction time abnormality
Inability to walk
Babinski sign
Peripheral neuropathy on nerve conduction studies
Cognitive impairment
Wheelchair
Spasticity, lower limb
Mri brain other abnormalities
Nerve conduction studies other abnormalities
Show more (+8)
n.a.
No
C
ITA
32
60
n.a.
Babinski sign
Spasticity, lower limb
Impaired vibratory sensation
Spastic gait
Central motor conduction time abnormality
Pes cavus
Show more (+3)
n.a.
No
C
ITA
41
66
n.a.
Cognitive impairment
Central motor conduction time abnormality
Spastic gait
Abnormality of the bladder
Walking aids
Peripheral neuropathy on nerve conduction studies
Mri brain other abnormalities
Spasticity, lower limb
Nerve conduction studies other abnormalities
Babinski sign
Show more (+7)
n.a.
No
C
ITA
26
49
n.a.
Abnormality of the bladder
Impaired vibratory sensation
Pes cavus
Spastic gait
Spasticity, lower limb
Babinski sign
Central motor conduction time abnormality
Show more (+4)
n.a.
No
C
ITA
26
46
n.a.
Impaired vibratory sensation
Pes cavus
Spasticity, lower limb
Spastic gait
Babinski sign
Central motor conduction time abnormality
Show more (+3)
n.a.
No
C
ITA
52
59
n.a.
Peripheral neuropathy on nerve conduction studies
Cognitive impairment
Babinski sign
Nerve conduction studies other abnormalities
Spastic gait
Walking aids
Spasticity, lower limb
Central motor conduction time abnormality
Mri brain other abnormalities
Abnormality of the bladder
Show more (+7)
n.a.
No
C
ITA
48
57
n.a.
Peripheral neuropathy on nerve conduction studies
Walking aids
Mri brain other abnormalities
Central motor conduction time abnormality
Babinski sign
Cognitive impairment
Abnormality of the bladder
Spastic gait
Nerve conduction studies other abnormalities
Spasticity, lower limb
Show more (+7)
n.a.
No
C
ITA
48
72
n.a.
Babinski sign
Abnormality of the bladder
Spastic gait
Walking aids
Cognitive impairment
Spasticity, lower limb
Central motor conduction time abnormality
Nerve conduction studies other abnormalities
Peripheral neuropathy on nerve conduction studies
Mri brain other abnormalities
Show more (+7)
n.a.