Orlacchio, 2005: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♀
|
C
|
ITA
|
25
|
46
|
n.a.
|
Spasticity, lower limb
Babinski sign Pes cavus Spastic gait Impaired vibratory sensation Central motor conduction time abnormality Show more (+3) |
n.a.
|
|
No
|
♀
|
C
|
ITA
|
23
|
41
|
n.a.
|
Central motor conduction time abnormality
Spasticity, lower limb Spastic gait Impaired vibratory sensation Babinski sign Abnormality of the bladder Pes cavus Show more (+4) |
n.a.
|
|
No
|
♂
|
C
|
ITA
|
49
|
75
|
n.a.
|
Abnormality of the bladder
Spastic gait Central motor conduction time abnormality Mri brain other abnormalities Spasticity, lower limb Cognitive impairment Wheelchair Babinski sign Inability to walk Peripheral neuropathy on nerve conduction studies Nerve conduction studies other abnormalities Show more (+8) |
n.a.
|
|
No
|
♀
|
C
|
ITA
|
32
|
60
|
n.a.
|
Pes cavus
Babinski sign Central motor conduction time abnormality Impaired vibratory sensation Spastic gait Spasticity, lower limb Show more (+3) |
n.a.
|
|
No
|
♂
|
C
|
ITA
|
41
|
66
|
n.a.
|
Babinski sign
Cognitive impairment Walking aids Abnormality of the bladder Peripheral neuropathy on nerve conduction studies Spasticity, lower limb Spastic gait Central motor conduction time abnormality Nerve conduction studies other abnormalities Mri brain other abnormalities Show more (+7) |
n.a.
|
|
No
|
♀
|
C
|
ITA
|
26
|
49
|
n.a.
|
Abnormality of the bladder
Impaired vibratory sensation Spastic gait Central motor conduction time abnormality Spasticity, lower limb Pes cavus Babinski sign Show more (+4) |
n.a.
|
|
No
|
♀
|
C
|
ITA
|
26
|
46
|
n.a.
|
Central motor conduction time abnormality
Impaired vibratory sensation Pes cavus Babinski sign Spasticity, lower limb Spastic gait Show more (+3) |
n.a.
|
|
No
|
♂
|
C
|
ITA
|
52
|
59
|
n.a.
|
Cognitive impairment
Babinski sign Spasticity, lower limb Mri brain other abnormalities Abnormality of the bladder Nerve conduction studies other abnormalities Walking aids Central motor conduction time abnormality Spastic gait Peripheral neuropathy on nerve conduction studies Show more (+7) |
n.a.
|
|
No
|
♂
|
C
|
ITA
|
48
|
57
|
n.a.
|
Abnormality of the bladder
Peripheral neuropathy on nerve conduction studies Mri brain other abnormalities Babinski sign Nerve conduction studies other abnormalities Spasticity, lower limb Spastic gait Central motor conduction time abnormality Cognitive impairment Walking aids Show more (+7) |
n.a.
|
|
No
|
♂
|
C
|
ITA
|
48
|
72
|
n.a.
|
Abnormality of the bladder
Cognitive impairment Babinski sign Spastic gait Central motor conduction time abnormality Mri brain other abnormalities Peripheral neuropathy on nerve conduction studies Walking aids Nerve conduction studies other abnormalities Spasticity, lower limb Show more (+7) |
n.a.
|