Orlacchio, 2005: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
C
ITA
25
46
n.a.
Spastic gait
Spasticity, lower limb
Babinski sign
Impaired vibratory sensation
Central motor conduction time abnormality
Pes cavus
Show more (+3)
n.a.
No
C
ITA
23
41
n.a.
Pes cavus
Spasticity, lower limb
Abnormality of the bladder
Spastic gait
Impaired vibratory sensation
Central motor conduction time abnormality
Babinski sign
Show more (+4)
n.a.
No
C
ITA
49
75
n.a.
Babinski sign
Central motor conduction time abnormality
Spasticity, lower limb
Cognitive impairment
Spastic gait
Nerve conduction studies other abnormalities
Wheelchair
Mri brain other abnormalities
Peripheral neuropathy on nerve conduction studies
Abnormality of the bladder
Inability to walk
Show more (+8)
n.a.
No
C
ITA
32
60
n.a.
Pes cavus
Spasticity, lower limb
Babinski sign
Spastic gait
Impaired vibratory sensation
Central motor conduction time abnormality
Show more (+3)
n.a.
No
C
ITA
41
66
n.a.
Cognitive impairment
Abnormality of the bladder
Nerve conduction studies other abnormalities
Spastic gait
Central motor conduction time abnormality
Peripheral neuropathy on nerve conduction studies
Walking aids
Babinski sign
Spasticity, lower limb
Mri brain other abnormalities
Show more (+7)
n.a.
No
C
ITA
26
49
n.a.
Babinski sign
Spasticity, lower limb
Spastic gait
Central motor conduction time abnormality
Pes cavus
Abnormality of the bladder
Impaired vibratory sensation
Show more (+4)
n.a.
No
C
ITA
26
46
n.a.
Spasticity, lower limb
Pes cavus
Spastic gait
Central motor conduction time abnormality
Impaired vibratory sensation
Babinski sign
Show more (+3)
n.a.
No
C
ITA
52
59
n.a.
Spasticity, lower limb
Peripheral neuropathy on nerve conduction studies
Walking aids
Cognitive impairment
Abnormality of the bladder
Mri brain other abnormalities
Nerve conduction studies other abnormalities
Central motor conduction time abnormality
Babinski sign
Spastic gait
Show more (+7)
n.a.
No
C
ITA
48
57
n.a.
Babinski sign
Cognitive impairment
Abnormality of the bladder
Spasticity, lower limb
Spastic gait
Walking aids
Peripheral neuropathy on nerve conduction studies
Central motor conduction time abnormality
Mri brain other abnormalities
Nerve conduction studies other abnormalities
Show more (+7)
n.a.
No
C
ITA
48
72
n.a.
Walking aids
Babinski sign
Central motor conduction time abnormality
Peripheral neuropathy on nerve conduction studies
Cognitive impairment
Spasticity, lower limb
Abnormality of the bladder
Mri brain other abnormalities
Nerve conduction studies other abnormalities
Spastic gait
Show more (+7)
n.a.