Nicholas, 2004: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
No
|
♀
|
n.a.
|
n.a.
|
17
|
64
|
n.a.
|
Pes cavus
Babinski sign Spastic gait Spasticity, lower limb Abnormality of the bladder Show more (+2) |
n.a.
|
|
Yes
|
♂
|
n.a.
|
n.a.
|
31
|
32
|
n.a.
|
n.a.
|
||
No
|
♂
|
n.a.
|
n.a.
|
20
|
20
|
n.a.
|
n.a.
|
||
No
|
♀
|
n.a.
|
n.a.
|
10
|
42
|
n.a.
|
Spastic gait
Pes cavus Abnormality of the bladder Hyperreflexia in upper limbs Spasticity, lower limb Babinski sign Show more (+3) |
n.a.
|
|
No
|
♂
|
n.a.
|
n.a.
|
n.a.
|
46
|
n.a.
|
Spasticity, lower limb
|
n.a.
|
|
No
|
♀
|
n.a.
|
n.a.
|
35
|
53
|
n.a.
|
Abnormality of the bladder
Babinski sign Pes cavus Spasticity, lower limb Lower limb muscle weakness Spastic gait Show more (+3) |
n.a.
|
|
No
|
♀
|
n.a.
|
n.a.
|
n.a.
|
74
|
n.a.
|
Hyporeflexia of lower limbs
Spastic gait Spasticity, upper limb |
n.a.
|
|
No
|
♀
|
n.a.
|
n.a.
|
12
|
14
|
n.a.
|
n.a.
|
||
No
|
♀
|
n.a.
|
n.a.
|
41
|
52
|
n.a.
|
Spasticity, lower limb
Spastic gait Babinski sign Abnormality of the bladder Lower limb muscle weakness Show more (+2) |
n.a.
|
|
No
|
♀
|
n.a.
|
n.a.
|
n.a.
|
32
|
n.a.
|
n.a.
|
n.a.
|