McDermott, 2001: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
No
C
GBR
72
77
n.a.
Spastic gait
Spasticity, lower limb
Abnormality of the bladder
Pes cavus
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n.a.
Yes
C
GBR
11
38
n.a.
Lower limb muscle weakness
Peripheral neuropathy on nerve conduction studies
Abnormality of the bladder
Muscle weakness, upper limb
Nerve conduction studies other abnormalities
Walking aids
Pes cavus
Spasticity, upper limb
Impaired vibratory sensation
Retinopathy
Upper limb amyotrophy
Babinski sign
Spasticity, lower limb
-Lower limb amyotrophy
Ataxia, limb
Spastic gait
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n.a.