Lindsey, 2000: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
n.a.
|
GBR
|
n.a.
|
11
|
n.a.
|
Impaired temperature sensation
Impaired vibratory sensation Hyperreflexia in upper limbs |
n.a.
|
|
Yes
|
♂
|
n.a.
|
GBR
|
60
|
75
|
n.a.
|
Spasticity, lower limb
Impaired vibratory sensation Pes cavus Abnormality of the bladder Lower limb muscle weakness Spastic gait Show more (+3) |
n.a.
|
|
Yes
|
n.a.
|
n.a.
|
GBR
|
40
|
70
|
No
|
-Lower limb amyotrophy
Pes cavus Upper limb amyotrophy |
n.a.
|
|
No
|
♀
|
n.a.
|
GBR
|
40
|
86
|
No
|
-Lower limb amyotrophy
Inability to walk Cognitive impairment Wheelchair Upper limb amyotrophy Pes cavus Spastic gait Show more (+4) |
n.a.
|
|
Yes
|
♂
|
n.a.
|
GBR
|
n.a.
|
n.a.
|
n.a.
|
Impaired pain sensation
-Pure or uncomplicated Spasticity, lower limb Cognitive impairment Impaired vibratory sensation -Lower limb amyotrophy Show more (+3) |
n.a.
|