Lindsey, 2000: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
n.a.
GBR
n.a.
11
n.a.
Hyperreflexia in upper limbs
Impaired temperature sensation
Impaired vibratory sensation
n.a.
Yes
n.a.
GBR
60
75
n.a.
Spastic gait
Spasticity, lower limb
Impaired vibratory sensation
Lower limb muscle weakness
Abnormality of the bladder
Pes cavus
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n.a.
p.Ser44Leu: het
Yes
n.a.
n.a.
GBR
40
70
No
-Lower limb amyotrophy
Pes cavus
Upper limb amyotrophy
n.a.
No
n.a.
GBR
40
86
No
Wheelchair
Pes cavus
Inability to walk
Spastic gait
Upper limb amyotrophy
-Lower limb amyotrophy
Cognitive impairment
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n.a.
Yes
n.a.
GBR
n.a.
n.a.
n.a.
-Lower limb amyotrophy
Spasticity, lower limb
-Pure or uncomplicated
Impaired pain sensation
Impaired vibratory sensation
Cognitive impairment
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n.a.