Brugman, 2005: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
C
|
NLD
|
50
|
53
|
No
|
Walking aids
Abnormality of the bladder Babinski sign -Pure or uncomplicated Lower limb muscle weakness Spasticity, lower limb Show more (+3) |
n.a.
|
|
Yes
|
♂
|
C
|
NLD
|
29
|
36
|
No
|
Lower limb muscle weakness
-Pure or uncomplicated Spasticity, lower limb Babinski sign Show more (+1) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
69
|
72
|
No
|
Lower limb muscle weakness
Babinski sign -Pure or uncomplicated Abnormality of the bladder Impaired vibratory sensation Spasticity, lower limb Show more (+3) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
33
|
34
|
No
|
Hyperreflexia in upper limbs
Spasticity, lower limb Wheelchair Babinski sign Lower limb muscle weakness Muscle weakness, upper limb Inability to walk Spasticity, upper limb Show more (+5) |
n.a.
|
|
Yes
|
♂
|
C
|
NLD
|
44
|
65
|
No
|
Lower limb muscle weakness
Hyperreflexia in upper limbs Babinski sign Impaired vibratory sensation Walking aids -Pure or uncomplicated Spasticity, lower limb Show more (+4) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
32
|
62
|
No
|
Babinski sign
Wheelchair Hyperreflexia in upper limbs Spasticity, lower limb Lower limb muscle weakness Abnormality of the bladder Show more (+3) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
50
|
54
|
No
|
-Pure or uncomplicated
Spasticity, lower limb Babinski sign Lower limb muscle weakness Show more (+1) |
n.a.
|