Brugman, 2005: Overview of all reported HSP-SPAST patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
C
NLD
50
53
No
Babinski sign
-Pure or uncomplicated
Abnormality of the bladder
Lower limb muscle weakness
Spasticity, lower limb
Walking aids
Show more (+3)
n.a.
Yes
C
NLD
29
36
No
-Pure or uncomplicated
Lower limb muscle weakness
Spasticity, lower limb
Babinski sign
Show more (+1)
n.a.
Yes
C
NLD
69
72
No
Lower limb muscle weakness
-Pure or uncomplicated
Babinski sign
Abnormality of the bladder
Spasticity, lower limb
Impaired vibratory sensation
Show more (+3)
n.a.
p.Glu442*: het
Yes
C
NLD
33
34
No
Babinski sign
Hyperreflexia in upper limbs
Spasticity, upper limb
Lower limb muscle weakness
Muscle weakness, upper limb
Wheelchair
Inability to walk
Spasticity, lower limb
Show more (+5)
n.a.
Yes
C
NLD
44
65
No
Impaired vibratory sensation
-Pure or uncomplicated
Lower limb muscle weakness
Hyperreflexia in upper limbs
Babinski sign
Spasticity, lower limb
Walking aids
Show more (+4)
n.a.
Yes
C
NLD
32
62
No
Lower limb muscle weakness
Abnormality of the bladder
Hyperreflexia in upper limbs
Wheelchair
Babinski sign
Spasticity, lower limb
Show more (+3)
n.a.
p.Arg581*: het
Yes
C
NLD
50
54
No
-Pure or uncomplicated
Spasticity, lower limb
Lower limb muscle weakness
Babinski sign
Show more (+1)
n.a.