Brugman, 2005: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
C
|
NLD
|
50
|
53
|
No
|
Lower limb muscle weakness
Babinski sign -Pure or uncomplicated Abnormality of the bladder Spasticity, lower limb Walking aids Show more (+3) |
n.a.
|
|
Yes
|
♂
|
C
|
NLD
|
29
|
36
|
No
|
Lower limb muscle weakness
Spasticity, lower limb -Pure or uncomplicated Babinski sign Show more (+1) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
69
|
72
|
No
|
Abnormality of the bladder
Babinski sign Spasticity, lower limb -Pure or uncomplicated Lower limb muscle weakness Impaired vibratory sensation Show more (+3) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
33
|
34
|
No
|
Hyperreflexia in upper limbs
Muscle weakness, upper limb Lower limb muscle weakness Babinski sign Spasticity, upper limb Spasticity, lower limb Wheelchair Inability to walk Show more (+5) |
n.a.
|
|
Yes
|
♂
|
C
|
NLD
|
44
|
65
|
No
|
-Pure or uncomplicated
Hyperreflexia in upper limbs Spasticity, lower limb Walking aids Impaired vibratory sensation Lower limb muscle weakness Babinski sign Show more (+4) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
32
|
62
|
No
|
Hyperreflexia in upper limbs
Abnormality of the bladder Wheelchair Babinski sign Spasticity, lower limb Lower limb muscle weakness Show more (+3) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
50
|
54
|
No
|
Babinski sign
-Pure or uncomplicated Lower limb muscle weakness Spasticity, lower limb Show more (+1) |
n.a.
|