Brugman, 2005: Overview of all reported HSP-SPAST patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
C
|
NLD
|
50
|
53
|
No
|
-Pure or uncomplicated
Babinski sign Spasticity, lower limb Abnormality of the bladder Walking aids Lower limb muscle weakness Show more (+3) |
n.a.
|
|
Yes
|
♂
|
C
|
NLD
|
29
|
36
|
No
|
Babinski sign
Spasticity, lower limb -Pure or uncomplicated Lower limb muscle weakness Show more (+1) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
69
|
72
|
No
|
-Pure or uncomplicated
Impaired vibratory sensation Abnormality of the bladder Babinski sign Lower limb muscle weakness Spasticity, lower limb Show more (+3) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
33
|
34
|
No
|
Babinski sign
Inability to walk Hyperreflexia in upper limbs Muscle weakness, upper limb Wheelchair Lower limb muscle weakness Spasticity, lower limb Spasticity, upper limb Show more (+5) |
n.a.
|
|
Yes
|
♂
|
C
|
NLD
|
44
|
65
|
No
|
Walking aids
-Pure or uncomplicated Lower limb muscle weakness Impaired vibratory sensation Hyperreflexia in upper limbs Spasticity, lower limb Babinski sign Show more (+4) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
32
|
62
|
No
|
Abnormality of the bladder
Wheelchair Spasticity, lower limb Lower limb muscle weakness Babinski sign Hyperreflexia in upper limbs Show more (+3) |
n.a.
|
|
Yes
|
♀
|
C
|
NLD
|
50
|
54
|
No
|
Spasticity, lower limb
Lower limb muscle weakness -Pure or uncomplicated Babinski sign Show more (+1) |
n.a.
|