Di Fonzo, 2009: Overview of all reported PARK-FBXO7 patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
No
|
♂
|
C
|
ITA
|
13
|
n.a.
|
n.a.
|
Spasticity/pyramidal signs
Tremor at rest Parkinsonism Bradykinesia Dysarthria/anarthria Postural instability Rigidity Dystonia Motor fluctuations Behavioral abnormalities Dysphagia Tremor, action Tremor (any or unspecified) Saccadic abnormalities Gaze palsy Dyskinesia Incontinence Atypical parkinsonism NMS parkinsonism Show more (+16) |
Rigidity
Tremor (any or unspecified) |
|
Yes
|
♀
|
C
|
ITA
|
10
|
n.a.
|
n.a.
|
Incontinence
Behavioral abnormalities Atypical parkinsonism Spasticity/pyramidal signs Dysarthria/anarthria Parkinsonism Tremor, action Rigidity Postural instability NMS parkinsonism Micrographia Bradykinesia Tremor at rest Motor fluctuations Dystonia Dyskinesia Tremor (any or unspecified) Dysphagia Show more (+15) |
Rigidity
Tremor (any or unspecified) |
|
Yes
|
♂
|
C
|
NLD
|
19
|
n.a.
|
n.a.
|
Behavioral abnormalities
Spasticity/pyramidal signs Tremor at rest Parkinsonism Postural instability Rigidity Dyskinesia NMS parkinsonism Dysphagia Atypical parkinsonism Motor fluctuations Bradykinesia Tremor (any or unspecified) Tremor, action Show more (+11) |
Behavioral abnormalities
Bradykinesia |
|
No
|
♀
|
C
|
NLD
|
18
|
n.a.
|
n.a.
|
Saccadic abnormalities
Behavioral abnormalities Gaze palsy Postural instability Spasticity/pyramidal signs Dyskinesia Bradykinesia Parkinsonism Motor fluctuations Tremor, action Atypical parkinsonism Tremor (any or unspecified) Rigidity Show more (+10) |
Behavioral abnormalities
Tremor (any or unspecified) |