Hatano, 2014: Overview of all reported PARK-LRRK2 patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
No
A
JPN
55
65
Yes
Atypical parkinsonism
Rigidity
-Motor
Bradykinesia
Depression
Cognitive decline
Psychotic sign/sympt.
Anxiety
NMS parkinsonism
Parkinsonism
Olfactory impairment
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Depression
Arg1441Gly: het
Yes
A
JPN
54
58
Yes
Bradykinesia
Rigidity
Postural instability
Parkinsonism
Tremor at rest
Tremor (any or unspecified)
-Motor
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n.a.
Gly2019Ser: het
No
A
JPN
28
44
Yes
Tremor at rest
Hyperreflexia
Motor fluctuations
Postural instability
-Motor
Tremor (any or unspecified)
Rigidity
Bradykinesia
NMS parkinsonism
Dyskinesia
Parkinsonism
Psychotic sign/sympt.
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Bradykinesia
Arg1441Gly: het
Yes
A
JPN
34
36
Yes
Bradykinesia
Hyperreflexia
Tremor at rest
-Motor
Sleep benefit
Rigidity
Tremor (any or unspecified)
Parkinsonism
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Tremor (any or unspecified)
Arg1441Gly: het