Marongiu, 2006: Overview of all reported PARK-LRRK2 patients

Index patient Sex Ethnicity Country of origin AAO AAE Family history Symptoms Initial symptoms Reported mutations
Yes
n.a.
ITA
40
41
No
-Motor
NMS parkinsonism
Bradykinesia
Tremor (any or unspecified)
Anxiety
Parkinsonism
Tremor at rest
Rigidity
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Rigidity
Gly2019Ser: het
Yes
n.a.
ITA
78
81
Yes
-Motor
Cognitive decline
Tremor at rest
Bradykinesia
Rigidity
Tremor (any or unspecified)
Parkinsonism
Dyskinesia
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Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
58
69
No
Rigidity
-Motor
Hyperreflexia
Bradykinesia
Parkinsonism
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Rigidity
Gly2019Ser: het
Yes
n.a.
ITA
55
75
Yes
-Motor
Dyskinesia
Bradykinesia
Rigidity
Parkinsonism
Motor fluctuations
NMS parkinsonism
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Rigidity
Gly2019Ser: het
Yes
n.a.
ITA
58
78
No
Dyskinesia
Motor fluctuations
Rigidity
Tremor at rest
Tremor (any or unspecified)
Parkinsonism
-Motor
Bradykinesia
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Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
57
65
Yes
Dyskinesia
-Motor
Rigidity
Autonomic sign/sympt.
NMS parkinsonism
Bradykinesia
Tremor at rest
Tremor (any or unspecified)
Parkinsonism
Motor fluctuations
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Rigidity
Gly2019Ser: het
Yes
n.a.
ITA
54
60
Yes
Depression
Parkinsonism
Tremor at rest
Rigidity
-Motor
Autonomic sign/sympt.
NMS parkinsonism
Tremor (any or unspecified)
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Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
35
40
No
-Motor
Parkinsonism
Rigidity
Hyperreflexia
Bradykinesia
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Bradykinesia
Gly2019Ser: het
Yes
n.a.
ITA
39
44
No
Tremor at rest
Dyskinesia
Tremor (any or unspecified)
Bradykinesia
Hyperreflexia
Rigidity
Anxiety
NMS parkinsonism
Parkinsonism
-Motor
Show more (+7)
Tremor (any or unspecified)
Gly2019Ser: het
Yes
n.a.
ITA
47
60
No
Rigidity
Tremor (any or unspecified)
Parkinsonism
Tremor at rest
Bradykinesia
-Motor
NMS parkinsonism
Depression
Show more (+5)
Tremor (any or unspecified)
Gly2019Ser: het