Goldwurm, 2005: Overview of all reported PARK-LRRK2 patients
| Index patient | Sex | Ethnicity | Country of origin | AAO | AAE | Family history | Symptoms | Initial symptoms | Reported mutations |
|---|---|---|---|---|---|---|---|---|---|
Yes
|
♂
|
C
|
ITA
|
49
|
64
|
Yes
|
Sleep disorder
Parkinsonism Tremor (any or unspecified) Bradykinesia Dystonia Tremor at rest Psychotic sign/sympt. Dyskinesia Rigidity NMS parkinsonism Postural instability Motor fluctuations -Motor Show more (+10) |
Tremor (any or unspecified)
Bradykinesia Rigidity |
|
Yes
|
♀
|
C
|
ITA
|
43
|
73
|
Yes
|
Rigidity
Cognitive decline NMS parkinsonism Depression -Motor Sleep disorder Motor fluctuations Tremor (any or unspecified) Dyskinesia Bradykinesia Parkinsonism Postural instability Tremor at rest Show more (+10) |
Tremor (any or unspecified)
Bradykinesia |
|
Yes
|
♀
|
C
|
ITA
|
44
|
61
|
No
|
Bradykinesia
-Motor Dystonia Motor fluctuations NMS parkinsonism Parkinsonism Sleep disorder Rigidity Dyskinesia Show more (+6) |
Bradykinesia
|
|
Yes
|
♂
|
C
|
ITA
|
72
|
81
|
Yes
|
Cognitive decline
Bradykinesia Rigidity Parkinsonism Tremor (any or unspecified) Postural instability NMS parkinsonism -Motor Tremor at rest Show more (+6) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
C
|
ITA
|
57
|
65
|
Yes
|
Depression
Dystonia Anxiety Tremor (any or unspecified) Bradykinesia Rigidity Sleep disorder NMS parkinsonism Dyskinesia Motor fluctuations -Motor Parkinsonism Tremor at rest Show more (+10) |
Depression
Tremor (any or unspecified) Rigidity |
|
Yes
|
♀
|
C
|
ITA
|
46
|
57
|
Yes
|
Parkinsonism
Tremor at rest Bradykinesia Rigidity Anxiety -Motor Motor fluctuations NMS parkinsonism Sleep disorder Sleep benefit Tremor (any or unspecified) Dyskinesia Show more (+9) |
Tremor (any or unspecified)
|
|
No
|
♂
|
C
|
ITA
|
66
|
81
|
Yes
|
Tremor at rest
Rigidity Tremor (any or unspecified) Parkinsonism Postural instability Bradykinesia -Motor Show more (+4) |
Tremor (any or unspecified)
|
|
Yes
|
♂
|
C
|
ITA
|
72
|
84
|
Yes
|
Cognitive decline
Postural instability Rigidity Depression Tremor (any or unspecified) NMS parkinsonism Tremor at rest -Motor Bradykinesia Parkinsonism Show more (+7) |
Tremor at rest
|
|
Yes
|
♂
|
C
|
ITA
|
51
|
63
|
No
|
Parkinsonism
Tremor (any or unspecified) Rigidity Bradykinesia Tremor at rest Postural instability -Motor Show more (+4) |
Tremor (any or unspecified)
Bradykinesia |
|
No
|
♂
|
C
|
ITA
|
67
|
73
|
Yes
|
Parkinsonism
-Motor |
n.a.
|