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Overview of included studies for PARK-LRRK2:
Click here for summary of patients' characteristics
Click here for summary of in vitro effect of mutations on LRRK2 kinase pathway activity
Click here for summary of genetic findings
Click here to show world map of all countries
Filter for
all included patients
index patients only
AAO < 50 (adjustable)
AAO >= 50 (adjustable)
females only
males only
homozygous only
heterozygous only
compound heterozygous only
homozygous and compound heterozygous
carrying
definitely pathogenic mutations
probably pathogenic mutations
possibly pathogenic mutations
c.1847A>G
c.2264C>T
c.2769G>C
c.4111A>G
c.4309A>C
c.4321C>A
c.4321C>G
c.4321C>T
c.4322G>A
c.5096A>G
c.5606T>C
c.5971A>G
c.6035T>C
c.6055G>A
c.6059T>C
c.632C>T
c.6523G>C
c.7067C>T
c.7153G>A
c.7315C>A
Country
Algeria
Argentina
Australia
Belgium
Brazil
Canada
Chile
China
Colombia
Denmark
Egypt
France
Germany
Greece
India
Iran
Ireland
Israel
Italy
Japan
Lithuania
Mexico
Morocco
Norway
Peru
Poland
Portugal
Puerto Rico
Russia
Serbia
Singapore
South Africa
South Korea
Spain
Sweden
Taiwan
Tunisia
Turkey
United Kingdom
United States
Study
Study design
N cases
Ethnicities
Sex
(%
♂
)
Mean AAO (+/- SD)
Reported mutations
Johnson, 2007
Mutational screen
1
C
100%
51
Thr2356Ile
: het
Perez-Pastene, 2007
Mutational screen
5
O
20%
61(+/-9)
Gly2019Ser
: het
Gly2019Ser
: hom
Lesage, 2007
Other/Mixed
4
n.a.
75%
60(+/-7)
Gly2019Ser
: het
González-Fernández, 2007
Mutational screen
22
n.a.
41%
56(+/-11)
Arg1441Gly
: het
Gly2019Ser
: het
Ferreira, 2007
Mutational screen
11
C
36%
54(+/-15)
Gly2019Ser
: het
Arg1441His
: het
Huang, 2007
Mutational screen
12
C
50%
60(+/-11)
Gly2019Ser
: het
Arg1441His
: het
Illarioshkin, 2007
Other/Mixed
5
n.a.
40%
51(+/-7)
Gly2019Ser
: het
Lesage, 2007
Mutational screen
6
C
50%
41(+/-10)
Gly2019Ser
: het
Squillaro, 2007
Case report/Case series
1
C
0%
47
Gly2019Ser
: het
Xiromerisiou, 2007
Mutational screen
2
n.a.
100%
69(+/-9)
Ala211Val
: het
Gly2019Ser
: het
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Dec. 2, 2020. Version: 3.5.95
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