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Overview of included studies for PARK-LRRK2:
Click here for summary of patients' characteristics
Click here for summary of in vitro effect of mutations on LRRK2 kinase pathway activity
Click here for summary of genetic findings
Click here to show world map of all countries
Filter for
all included patients
index patients only
AAO < 50 (adjustable)
AAO >= 50 (adjustable)
females only
males only
homozygous only
heterozygous only
compound heterozygous only
homozygous and compound heterozygous
carrying
definitely pathogenic mutations
probably pathogenic mutations
possibly pathogenic mutations
c.1847A>G
c.2264C>T
c.2769G>C
c.4111A>G
c.4309A>C
c.4321C>A
c.4321C>G
c.4321C>T
c.4322G>A
c.5096A>G
c.5606T>C
c.5971A>G
c.6035T>C
c.6055G>A
c.6059T>C
c.632C>T
c.6523G>C
c.7067C>T
c.7153G>A
c.7315C>A
Country
Algeria
Argentina
Australia
Belgium
Brazil
Canada
Chile
China
Colombia
Denmark
Egypt
France
Germany
Greece
India
Iran
Ireland
Israel
Italy
Japan
Lithuania
Mexico
Morocco
Norway
Peru
Poland
Portugal
Puerto Rico
Russia
Serbia
Singapore
South Africa
South Korea
Spain
Sweden
Taiwan
Tunisia
Turkey
United Kingdom
United States
Study
Study design
N cases
Ethnicities
Sex
(%
♂
)
Mean AAO (+/- SD)
Reported mutations
Infante, 2006
Mutational screen
8
H
25%
69(+/-6)
Gly2019Ser
: het
Kay, 2006
Other/Mixed
18
n.a.
67%
54(+/-12)
Gly2019Ser
: het
Gly2019Ser
: hom
Goldwurm, 2005
Other/Mixed
22
n.a.
59%
54(+/-13)
Gly2019Ser
: het
Khan, 2005
Mutational screen
13
C
62%
50(+/-8)
Tyr1699Cys
: het
Gly2019Ser
: het
Berg, 2005
Mutational screen
2
n.a.
0%
50(+/-10)
Ile2020Thr
: het
Gly2019Ser
: het
Lesage, 2005
Other/Mixed
12
n.a.
n.a.
59(+/-14)
Gly2019Ser
: het
Mata, 2005
Mutational screen
6
n.a.
67%
56(+/-10)
Arg1441Cys
: het
Arg1441Gly
: het
Arg1441His
: het
Gly2019Ser
: het
Gly2385Arg
: het
Met1869Thr
: het
Show more (+3)
Zabetian, 2005
Mutational screen
5
C
n.a.
52(+/-14)
Arg1441Cys
: het
Arg1441His
: het
Gly2019Ser
: het
Gly2019Ser
: hom
Show more (+1)
Farrer, 2005
Mutational screen
4
C
75%
55(+/-11)
Gly2019Ser
: het
Paisán-Ruíz, 2005
Mutational screen
5
C
n.a.
61(+/-15)
Gly2019Ser
: het
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